Journal
JOURNAL OF VIROLOGY
Volume 76, Issue 1, Pages 421-426Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.1.421-426.2002
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Funding
- NCI NIH HHS [CA68051, R01 CA068051] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA068051] Funding Source: NIH RePORTER
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We sequenced the rhesus lymphocryptovirus (LCV) genome in order to determine its genetic similarity to Epstein-Barr virus (EBV). The rhesus LCV encodes a repertoire identical to that of EBV, with 80 open reading frames, including cellular interleukin-10, bcl-2, and colony-stimulating factor 1 receptor homologues and an equivalent set of viral glycoproteins. The highly conserved rhesus LCV gene repertoire provides a unique animal model for the study of EBV pathogenesis.
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