4.7 Article

Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 3, Pages 212-213

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b107829c

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Quinoxaline, found in antitumor quinoxaline antibiotics, was found to cleave double stranded DNA at the 5 side guanine of 5'-GG-3' site on irradiation with long wavelength UV light without any additive; furthermore, a bis(quinoxaline-carbohydrate) hybrid system was very effective for DNA cleavage.

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