Journal
INFECTION AND IMMUNITY
Volume 70, Issue 3, Pages 1623-1626Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.70.3.1623-1626.2002
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- Wellcome Trust [063643] Funding Source: Medline
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Immunization with DNA followed by modified vaccinia virus Ankara strain, both expressing the antigen 85A, induced both CD4(+)- and CD8(+)-T-cell responses in BALB/c mice. Following challenge with Mycobacterium tuberculosis, this prime-boost regimen produced protection equivalent to that conferred by Mycobacterium bovis BCG. Following immunization with dendritic cells pulsed with an antigen 85A CD4(+)- or CD8(+)-restricted epitope, alone or in combination, copresentation of both epitopes on the same dendritic cell was required for protection, demonstrating that induced CD8(+) T cells can play a protective role against tuberculosis.
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