Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 46, Issue 3, Pages 882-883Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.46.3.882-883.2002
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI028855, R01AI028855] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI028855, AI28855, R56 AI028855] Funding Source: Medline
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New drugs and molecular targets are needed against Trypanosoma brucei, the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 muM.
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