Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 46, Issue 3, Pages 929-931Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.46.3.929-931.2002
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI004717, N01AI035174, R37AI004717] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM050694] Funding Source: NIH RePORTER
- NIAID NIH HHS [N01-AI-35174, AI04717] Funding Source: Medline
- NIGMS NIH HHS [GM-50694, R01 GM050694] Funding Source: Medline
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The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice.
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