Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 22, Issue 1, Pages 207-220Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.22.1.207-220.2002
Keywords
-
Categories
Funding
- NATIONAL CANCER INSTITUTE [T32CA009594] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM061712, T32GM007183] Funding Source: NIH RePORTER
- NCI NIH HHS [5T32CA09594, T32 CA009594] Funding Source: Medline
- NIGMS NIH HHS [5T32GM07183, T32 GM007183, GM61712, R01 GM061712] Funding Source: Medline
Ask authors/readers for more resources
Binding of either ligand or agonistic antibodies to the death receptor CD95 (APO-1/Fas) induces the formation of the death-inducing signaling complex (DISC). We now show that signal initiation of CD95 in type I cells can be further separated into at least four distinct steps. (i) The first step is ligand-induced formation of CD95 microaggregates at the cell surface. (ii) The second step is recruitment of FADD to form a DISC. This step is dependent on actin filaments. (iii) The third step involves formation of large CD95 surface clusters. This event is positively regulated by DISC-generated caspase 8. (iv) The fourth step is internalization of activated CD95 through an endosomal pathway. The latter step is again dependent on the presence of actin filaments. The data indicate that the signal initiation by CD95 is a complex process actively regulated at various levels, providing a number of new drug targets to specifically modulate CD95 signaling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available