Journal
ANESTHESIOLOGY
Volume 96, Issue 1, Pages 183-188Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00000542-200201000-00032
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K08HL003690, R01HL063705] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R21AA012331] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL 63705, HL 54280, HL 03690] Funding Source: Medline
- NIAAA NIH HHS [AA 12331] Funding Source: Medline
- NIGMS NIH HHS [GM 08377] Funding Source: Medline
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Background: Volatile anesthetics stimulate but hyperglycemia attenuates activity of mitochondrial adenosine triphosphate-regulated potassium channels. The authors tested the hypothesis that acute hyperglycemia interferes with isoflurane-induced preconditioning in vivo. Methods: Barbiturate-anesthetized dogs (n=79) were instrumented for measurement of hemodynamics. Myocardial infarct size and collateral blood flow were assessed with triphenyltetrazolium chloride staining and radioactive microspheres, respectively. All dogs were subjected to a 60-min left anterior descending coronary artery occlusion followed by 3 h of reperfusion. Dogs were randomly assigned to receive an infusion of normal saline (normoglycemic controls) or 15% dextrose in water to increase blood glucose concentrations to 300 or 600 mg/dl in the absence or presence of isoflurane (0.5 or 1.0 minimum alveolar concentration [MAC]) in separate experimental groups. Isoflurane was discontinued, and blood glucose concentrations were allowed to return to baseline values before left anterior descending coronary artery occlusion. Results: Myocardial infarct size was 26+/-1% of the left ventricular area at risk in control experiments. Isoflurane reduced infarct size (15+/-2 and 13+/-1% during 0.5 and 1.0 MAC, respectively). Hyperglycemia alone did not alter infarct size (26+/-2 and 33+/-4% during 300 and 600 mg/dl, respectively). Moderate hyperglycemia blocked the protective effects of 0.5 MAC (25+/-2%) but not 1.0 MAC isoflurane (13+/-2%). In contrast, severe hyperglycemia prevented reductions of infarct size during both 0.5 MAC (29+/-3%) and 1.0 MAC isoflurane (28+/-4%). Conclusions: Acute hyperglycemia attenuates reductions in myocardial infarct size produced by isoflurane in dogs.
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