Journal
OSTEOPOROSIS INTERNATIONAL
Volume 13, Issue 3, Pages 218-221Publisher
SPRINGER-VERLAG LONDON LTD
DOI: 10.1007/s001980200017
Keywords
bone mineral density; Chinese; Fok I polymorphism of the vitamin D gene; vertebral fracture
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The relationship between Fok I polymorphism of the vitamin D receptor start codon, bone mineral density (BMD) and vertebral fractures was studied in 684 Chinese men and women. A significant trend was observed only in Chinese women aged 70-79 years. The mean BMD at the total body was 0.85 +/- 0.01 g/cm(2), 0.82 +/- 0.01 g/cm(2) and 0.84 +/- 0.01 g/cm(2) for elderly women of the FF, Ff and ff genotypes respectively (p = 0.06 by ANOVA). Similar but statistically non-significant trends were observed at the hip and spine. However, no association between BMD and the Fok I genotype was observed in younger women (aged 50-59 years) and elderly men (aged 70-79 years). In all study groups, there was no effect of an interaction between Fok I polymorphism and calcium intake on BMD (p > 0.05 for the interaction effects by two-way ANOVA). No significant association was observed between Fok I polymorphism and vertebral fracture in elderly men or women (p > 0.05 by the chi-square test). We conclude that the Fok I polymorphism may have a weak effect on the BMD of elderly Chinese women.
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