Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 116, Issue 1, Pages 155-157Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2002.03241.x
Keywords
beta-thalassaemia; chronic myeloid leukaemia; anagrelide; hydroxyurea; haemoglobin F
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The co-existence of thalassaemia major and chronic myeloid leukaemia (CML) is a very rare event. We report a 32-year-old man with thalassaemia major whose progressively increasing leukocytosis and thrombocytosis led to the diagnosis of CML confirmed by the characteristic t(9;22)(q34;q11) chromosomal translocation and the bcr-abl (b3a2) DNA fusion. The patient was treated with hydroxyurea and anagrelide. This combination resulted in the satisfactory control of both the white blood cell and platelet counts, which has continued over the past 14 months with no major side-effects, albeit with no molecular response. The administration of hydroxyurea was also associated with a significant HbF increase.
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