Journal
VIROLOGY
Volume 294, Issue 1, Pages 70-74Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/viro.2001.1320
Keywords
influenza; membrane fusion; hemagglutinin; structure; antibody
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We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition. (C) 2002 Elsevier Science (USA).
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