Journal
CELLULOSE
Volume 20, Issue 2, Pages 873-884Publisher
SPRINGER
DOI: 10.1007/s10570-012-9847-5
Keywords
Cellulose; Poly(L-lactide); ROP; Core-shell micelle; Self-assembly
Funding
- National Natural Science Foundation of China [51103046]
- Ministry of Science and Technology, 973 projects [2010CB732201, 2010CB732204]
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In this paper, a novel biodegradable biomass-based amphiphile was prepared by direct grafting copolymerization of dissolved pulp with hydrophobic poly (l-lactide) in ionic liquids BmimCl. The molecular structures of the obtained copolymers were confirmed with H-1-NMR, C-13-NMR and 2D HSQC NMR, and their physical properties were studied by TGA and XRD analysis. The self-assembly behaviors of these amphiphilies in aqueous solution was characterized by fluorescence spectrum and their critical micelle concentrations (CMC) were determined to be in the range of 0.326-0.062 mg/mL. TEM observations and DLS analysis revealed that the pulp-derived micelles had spherical and uniform morphology and small diameters (25-125 nm). It was also found that the surface tension of these copolymers solution firstly decreased dramatically with increasing concentration and then approached to a plateau value when the concentration was above their CMC value. MTT assay showed that the pulp-derived amphiphilic micelles exhibited good biocompatibility, which informed that these micelles could be expected to be used in biological regions, especially for the hydrophobic drug delivery system.
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