Journal
SYNTHETIC COMMUNICATIONS
Volume 32, Issue 12, Pages 1847-1851Publisher
MARCEL DEKKER INC
DOI: 10.1081/SCC-120004068
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Dihydropyrimidines are prepared by a one-pot cyclocondensation of aldehydes, beta-ketoesters and urea with p-toluenesulfonic acid-catalyzed condensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction conditions.
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