Journal
AMERICAN JOURNAL OF PATHOLOGY
Volume 160, Issue 1, Pages 151-164Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0002-9440(10)64359-3
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Funding
- NCI NIH HHS [P30 CA082103, CA82103] Funding Source: Medline
- NCRR NIH HHS [M01-RR-00079, M01 RR000079, M01-RR-0083, M01 RR000083] Funding Source: Medline
- NIAID NIH HHS [U01 AI042590, U01-AI-34989, U01 AI034989, U01-AI-31834, AI-34989, U01 AI034994, U01-AI-34994, U01-AI-35004, U01 AI034993, U01-AI-42590, U01 AI031834, U01 AI035004, U01-AI-34993] Funding Source: Medline
- NICHD NIH HHS [U01-HD-32632, U01 HD032632] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [U01HD032632] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [P30CA082103] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000079, M01RR000083] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI031834, U01AI035004, U01AI034989, U01AI042590, U01AI034994, U01AI034993] Funding Source: NIH RePORTER
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The exact role of the mucosal immune response in the pathogenesis of human papillomavirus (HPV)-related premalignant and malignant diseases of the genital tract is poorly understood. We used immunohistochemical analysis to characterize immune cells In normal cervix (N = 21), HIV-negative high-grade dysplasia (N = 21), and HIV-positive high-grade dysplasia (N = 30). Classical germinal centers were present in 4.7% of normal cervix, 33% of high-grade lesions from HIV-negative women, and 3.3% of high-grade lesions from HIV-positive women (P = 0.003). HPV16 E7 antigen was detected in a subset of germinal centers, indicating that the secondary immune response was directed in part against HPV. Lymphoid follicles were present in 9.5% of normal cervix, 57% of HIV-negative high-grade dysplasia, and 50% of HIV-positive high-grade dysplasia (P = 0.001 normal versus high-grade). A novel type of lymphoid aggregate, consisting predominantly of CD8(+) T cells, was detected in 4.8% of normal cervix, 0% of HIV-negative high- grade dysplasia, and 40% of HIV-positive high-grade dysplasia (P < 0.001). The recurrence rate of high-grade dysplasia within one year was significantly higher in women with such CD8(+) T cell-dominant aggregates (P = 0.02). In summary, the types of lymphoid follicle in lesions from HIV-positive women were significantly different from those from HIV-negative women, and these differences are associated with the worse clinical outcome in HIV-positive women.
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