Journal
AMERICAN JOURNAL OF KIDNEY DISEASES
Volume 39, Issue 1, Pages 24-27Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/ajkd.2002.29873
Keywords
complement; glomerulonephritis; human; factor H-related proteins
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Factor H-related protein-5 (FHR-5) is a newly described human plasma protein with structural similarities to human factor H and the four other recently described factor H-related proteins. Unlike the other factor H-related proteins, FHR-5 was initially identified at the protein, rather than complementary DNA, level In studies of glomerular immune deposit composition. To determine the incidence and pattern of detection of FHR-5 in human renal biopsy specimens, a prospective study of 100 consecutive biopsies was performed using anti-FHR-5 monoclonal antibody and indirect immunofluorescence. The pattern of FHR-5 deposition is very similar to that of other complement components, C3 and SC5b-9. It is detected in all complement-containing glomerular Immune deposits and has a pattern of extraglomerular deposition similar to that of other complement components. This study shows FHR-5 to be strongly associated with glomerular complement deposition and suggests a role In complement activation or regulation. It may be an important mediator of glomerular disease. (C) 2002 by the National Kidney Foundation, Inc.
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