Interpenetrating polymer network microspheres of hydroxy propyl methyl cellulose/poly (vinyl alcohol) for control release of ciprofloxacin hydrochloride

Hydroxypropylmethylcellulose and Poly (vinyl alcohol) blend microspheres were prepared by water in oil emulsion method and Ciprofloxacin Hydrochloride (CFHcl) was loaded into the interpenetrating polymer network (IPN) microspheres that are crosslinked with glutaraldehyde (GA). Blend microspheres were characterized using Fourier transform infrared Spectroscopy (FT-IR), Scanning electron microscopy, X-ray diffraction and Differential scanning Calorimetry. FTIR spectra results confirmed crosslinking reaction between -OH groups of Poly (vinyl alcohol) and -CHO groups of glutaraldehyde. Scanning electron micrograph showed the formation of plain, uniform and smooth microspheres. X-ray diffraction and thermal studies of plain and drug loaded microspheres indicates that the drug is dispersed at the molecular level in the IPN matrix. In vitro dissolution experiments were performed in pH 7.4 buffer medium at 35 A degrees C which indicates a sustained and controlled release of ciprofloxacin hydrochloride (CFHcl) from the IPN microspheres up to 10 h.