Journal
CELLULAR SIGNALLING
Volume 26, Issue 9, Pages 1888-1896Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2014.05.006
Keywords
microRNA; Adipogenesis; Obesity; Therapeutic; Adipocyte differentiation; Lipid metabolism
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Funding
- National Natural Science Foundation of China [31272425]
- National Science & Technology Pillar Program [2011BAD28B01]
- Science and Technology Planning Project of Hubei Province, China [2011BBB090]
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Obesity is a serious health problem worldwide associated with an increased risk of life-threatening diseases such as type 2 diabetes, atherosclerosis, and certain types of cancer. Understanding the molecular basis of adipogenesis and fat cell development in obesity is essential to identify new biomarkers and therapeutic targets for the development of anti-obesity drugs. Recent computational and experimental studies have shown that microRNAs (miRNAs) appear to play regulatory roles in many biological processes associated with obesity, including adipocyte differentiation and lipid metabolism. In addition, many miRNAs are dysregulated in metabolic tissues from obese animals and humans, which potentially contributes to the pathogenesis of obesity-associated complications. The discovery of circulating miRNAs has highlighted their potential as both endocrine signaling molecules and disease markers. The potential of miRNA based therapeutics targeting obesity is highlighted as well as recommendations for future research which could lead to a breakthrough in the treatment of obesity. (C) 2014 Elsevier Inc. All rights reserved.
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