Journal
SYNTHETIC COMMUNICATIONS
Volume 32, Issue 4, Pages 527-533Publisher
MARCEL DEKKER INC
DOI: 10.1081/SCC-120002397
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The synthesis of 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466. 1), the prototype of a series of noncompetitive AMPA receptor antagonists, and its 3,4-dihydroderivative (GYKI 52895, 2) is described. The title compounds have been prepared starting from safrole through a quite effective procedure.
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