Journal
BIOTECHNOLOGY LETTERS
Volume 24, Issue 6, Pages 455-458Publisher
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1014553109425
Keywords
clavulanic acid; feeding; glycerol; Streptomyces clavuligerus
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Glycerol at 10-20 g l(-1) increased clavulanic acid production by Streptomyces clavuligerus in shake-flask culture. The biosynthesis of clavulanic acid continued for longer by feeding glycerol and production increased to 250 mg l(-1) compared with 115 mg l(-1) without feeding. In fermenter batch culture, degradation of clavulanic acid began after 72 h. With glycerol feeding in fed-batch culture, clavulanic acid production was not only increased further to about 280 mg l(-1) but also remained stable up to 130 h.
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