Journal
CELLULAR SIGNALLING
Volume 25, Issue 12, Pages 2548-2557Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2013.08.007
Keywords
Redox signaling; Redox-sensitive transcription factors; Nuclear factor erythroid 2-related factor 2 (Nrf2); Nuclear factor kappa B (NF-kappa B)
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Funding
- Doctoral Program in Biomedical Sciences, School of Medicine, National Autonomous University of Mexico (UNAM)
- CONACYT
- National Council of Science and Technology (CONACyT), Mexico [177527]
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Moderate concentrations of reactive oxygen species (ROS) are produced by diverse sources under physiological conditions. At such low levels, these molecules may act as upstream mediators of relevant signaling pathways: however an increase in their concentration with respect to the antioxidant system activity, changes their redox signaling function into a deleterious role. Thus, cell health depends, at least in part, on redox balance. This review includes global aspects of oxygen chemistry, ROS generation, antioxidant system, and redox signaling. It is also focused on the description of two relevant redox-sensitive transcription factors: nuclear factor erythroid 2-related factor 2 (Nrf2), which may be a potential target to confer cell protection, and nuclear factor kappa B (NF-kappa B), which is involved in deleterious effects in the cell. Finally, recent findings on the interplay between both factors for the development of different pathologies are discussed. (C) 2013 Elsevier Inc. All rights reserved.
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