Journal
CELLULAR SIGNALLING
Volume 25, Issue 9, Pages 1924-1931Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2013.05.007
Keywords
Signal transducers and activators of transcription; Jak tyrosine kinase; Histone deacetylase; Histone acetyltransferase; Acetylation
Categories
Funding
- National Institutes of Health [DK-085065]
- National Nature Science Foundation of China [81270778]
- Pudong New District Foundation of China [PWZxk2010-02]
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Signal transducers and activators of transcription (STAT) belong to a family of latent cytoplasmic factors that can be activated by tyrosine phosphorylation by the members of the Jak tyrosine kinase family in response to a variety of cytokines and growth factors. Activated STATs form dimers and translocate into nucleus to induce expression of critical genes essential for normal cellular events. In the past several years, significant progress has been made in the characterization of STAT acetylation, which is dependent on the balance between histone deacetylases (HDACs) and histone acetyltransferases (HATS) such as CBP/p300. Acetylation of STAT1, STAT2, STAT3, STAT5b and STAT6 has been identified. This review will highlight acetylation on the modulation of STAT activation. (C) 2013 Elsevier Inc. All rights reserved.
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