Visible-light-induced photocatalytic trifluoromethylation/1,2-carbon migration sequences for the synthesis of CF3-substituted cyclic ketones

A visible-light-induced photoredox trifluoromethylation/1,2-carbon migration sequence of alkenols is described. This approach provides a mild and operationally simple access to the synthesis of CF3-substituted cyclic ketones via trifluoromethylation and 1,2-carbon migration of 1-(1-arylvinyl)cyclobutanol derivatives. (C) 2015 Elsevier B.V. All rights reserved.