Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 172, Issue -, Pages 13-21Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2015.01.004
Keywords
N-Sulfonyl imines; alpha,alpha-Difluoroenolates; Fluoro-ketone; C-C bond cleavage; Mannich reaction
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Funding
- National Natural Science Foundation of China [21102071]
- Jiangsu 333 program
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Mannich addition reactions between in situ generated alpha,alpha-difluoroenolates and various N-sulfonyl imines readily occur with exceptionally high reaction rates at ambient temperature. The method features remarkable generality and enjoys operationally convenient conditions underscoring its practicality and methodological importance for preparation of sulfonamides bearing beta-amino-alpha,alpha-difluoro ketone moiety. (C) 2015 Elsevier B.V. All rights reserved.
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