Journal
CELLULAR SIGNALLING
Volume 24, Issue 6, Pages 1251-1260Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2012.02.010
Keywords
Sleep loss; Learning; Hippocampus; Astrocytes; cAMP; Transcription
Categories
Funding
- Netherlands Organization for Scientific Research (NWO) [825.07.029]
- NIA [5P01AG017628-09]
- NIMH [R01 MH086415-01]
- NRSA [MH090711NRSA]
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Sleep deprivation is a common feature in modern society, and one of the consequences of sleep loss is the impairment of cognitive function. Although it has been widely accepted that sleep deprivation affects learning and memory, only recently has research begun to address which molecular signaling pathways are altered by sleep loss and, more importantly, which pathways can be targeted to reverse the memory impairments resulting from sleep deprivation. In this review, we discuss the different methods used to sleep deprive animals and the effects of different durations of sleep deprivation on learning and memory with an emphasis on hippocampus-dependent memory. We then review the molecular signaling pathways that are sensitive to sleep loss, with a focus on those thought to play a critical role in the memory and synaptic plasticity deficits observed after sleep deprivation. Finally, we highlight several recent attempts to reverse the effects of sleep deprivation on memory and synaptic plasticity. Future research building on these studies promises to contribute to the development of novel strategies to ameliorate the effects of sleep loss on cognition. (c) 2012 Elsevier Inc. All rights reserved.
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