Journal
CELLULAR SIGNALLING
Volume 24, Issue 3, Pages 606-611Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2011.11.016
Keywords
Receptor tyrosine kinase; Ephrin; Alzheimer's disease; Dendritic spine; Glutamate receptor
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Funding
- Research Grants Council of Hong Kong (HKUST) [661109, 660810, 660110]
- Innovation and Technology Fund [UIM/198]
- University Grants Committee [AoE/B-15/01]
- Hong Kong Jockey Club
- Croucher Foundation
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Precise regulation of synapse formation, maintenance and plasticity is crucial for normal cognitive function, and synaptic failure has been suggested as one of the hallmarks of neurodegenerative diseases. In this review, we describe the recent progress in our understanding of how the receptor tyrosine kinase Ephs and their ligands ephrins regulate dendritic spine morphogenesis, synapse formation and maturation, as well as synaptic plasticity. In particular, we discuss the emerging evidence implicating that deregulation of Eph/ephrin signaling contributes to the aberrant synaptic functions associated with cognitive impairment in Alzheimer's disease. Understanding how Eph/ephrin regulates synaptic function may therefore provide new insights into the development of therapeutic agents against neurodegenerative diseases. (C) 2011 Elsevier Inc. All rights reserved.
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