Journal
JOURNAL OF NATURAL PRODUCTS
Volume 65, Issue 3, Pages 411-413Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np010480n
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A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46 mug/mL.
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