Journal
MICROBIOLOGY-SGM
Volume 148, Issue -, Pages 773-782Publisher
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/00221287-148-3-773
Keywords
quorum sensing; LuxS; swarming; virulence; urinary tract infection
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Funding
- NIDDK NIH HHS [DK49720] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK049720] Funding Source: NIH RePORTER
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Quorum sensing regulates the expression of virulence factors in a wide variety of pathogenic bacteria. This study has shown that Proteus mirabilis harbours a homologue of luxS, a gene required for the synthesis of the quorum sensing autoinducer 2 (AI-2). AI-2 activity is expressed during and is correlated with the initiation of swarming migration on agar surfaces. The P. mirabilis luxS locus was cloned and a LuxS(-) strain constructed by allelic-exchange mutagenesis. While lacking AI-2 activity, a null mutation in luxS, however, did not affect swimming or swarming motility, swarmer cell differentiation, or virulence in a mouse model of ascending urinary tract infection.
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