Journal
CELLULAR SIGNALLING
Volume 24, Issue 9, Pages 1856-1862Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2012.05.013
Keywords
Hyaluronan; CD44; IQGAP1; Cell migration; Cell proliferation; Rho-family GTPases
Categories
Funding
- Swedish Cancer Society
- Wenner-Gren Foundation
- Agnes and Mac Rudberg Foundation
- Gurli and Edward Brunnberg Foundation
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IQGAP1, an essential scaffolding protein, forms a complex with the hyaluronan receptor CD44. In this study, we have examined the importance of IQGAP1 for hyaluronan-mediated fibroblast migration and proliferation. Hyaluronan induced formation of F-actin fibers and focal adhesions, which was dependent on IQGAP1. IQGAP1 was required for hyaluronan- but not for platelet-derived growth factor (PDGF)-BB-induced cell migration, and was required for both hyaluronan- and PDGF-BB-mediated fibroblast proliferation, but not for proliferation induced by 10% fetal bovine serum. Depletion of IQGAP1 suppressed hyaluronan-induced activation of Rac1 and enhanced the activation of RhoA. Taken together, these findings indicate important roles for IQGAP1 in hyaluronan-stimulated migration and proliferation of fibroblasts. (C) 2012 Elsevier Inc. All rights reserved.
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