Journal
CELLULAR SIGNALLING
Volume 23, Issue 3, Pages 516-521Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2010.09.012
Keywords
Rab7; Endo-lysosomal traffic; HOPs; RILP; ORP1L; FYCO1
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Funding
- National Natural Science Foundation of China [30971442, 30928011]
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Protein-protein interaction cascades are crucial for cellular signaling pathways and cell morphogenesis. Membrane traffic along the secretory and endocytic pathways is similarly governed by regulated protein-protein interactions of diverse machineries, which are inter-regulated, assembled and disassembled sequentially to drive membrane budding, vesicle transport, membrane fission and fusion. Rab7, the key regulator in endo-lysosomal trafficking investigated extensively in the past decades, is emerging to govern early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. We summarize here the key protein interaction cascades of Rab7 by focusing on endo-lysosomal trafficking regulated by its interaction with HOPs, RILP, ORP1L, FYCO1 and Mon1/Sand1-CCZ1 complex. (C) 2010 Elsevier Inc. All rights reserved.
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