Journal
CELLULAR SIGNALLING
Volume 23, Issue 10, Pages 1546-1554Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2011.05.022
Keywords
Insulin signalling; Rac1; Actin; GLUT4; Skeletal muscle
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Funding
- Canadian Institutes of Health Research [MOT 7307]
- Danish Medical Research Council
- Lundbeck Foundation
- NovoNordisk Foundation
- National Science and Engineering Research Council
- Research Training Centre from The Hospital for Sick Children
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Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle. (C) 2011 Elsevier Inc. All rights reserved.
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