Journal
CELLULAR SIGNALLING
Volume 23, Issue 10, Pages 1528-1533Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2011.05.008
Keywords
Insulin resistance; Diabetes; Mitochondria; ER stress; Unfolded protein response
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Funding
- NIDDK NIH HHS [R01 DK076902, R01 DK076902-03] Funding Source: Medline
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Under pathophysiological conditions such as obesity, excessive oxidation of nutrients may induce mitochondrial stress, leading to mitochondrial unfolded protein response (UPRmt) and initiation of a retrograde stress signaling pathway. Defects in the UPRmt and the retrograde signaling pathways may disrupt the integrity and homeostasis of the mitochondria, resulting in endoplasmic reticulum stress and insulin resistance. Improving the capacity of mitochondria to reduce stress may be an effective approach to improve mitochondria function and to suppress obesity-induced metabolic disorders such as insulin resistance and type 2 diabetes. (C) 2011 Elsevier Inc. All rights reserved.
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