Journal
CELLULAR SIGNALLING
Volume 22, Issue 7, Pages 977-983Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2010.01.010
Keywords
TNF-alpha; Neuroinflammation; Alzheimer's; Parkinson's; Synaptic plasticity; Ionic homeostasis
Categories
Funding
- NIA NIH HHS [R01 AG026328-03, R01 AG026328] Funding Source: Medline
- NINDS NIH HHS [F31 NS056731-03] Funding Source: Medline
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Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory molecule, which upon engagement with its cognate receptors on target cells, triggers downstream signaling cascades that control a number of cellular processes related to cell viability, gene expression, ion homeostasis, and synaptic integrity. In the central nervous system (CNS), TNF-alpha is produced by brain-resident astrocytes, microglia, and neurons in response to numerous intrinsic and extrinsic stimuli. This review will summarize the key events that lead to TNF-alpha elaboration in the CNS, and the effects that these inflammatory signals impart on neuronal signaling in the context of homeostasis and neuropathology. (C) 2010 Elsevier Inc. All rights reserved.
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