Journal
CELLULAR SIGNALLING
Volume 22, Issue 10, Pages 1397-1405Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2010.03.018
Keywords
Dendritic cells; Pathogen recognition receptor; Adhesion; Migration; Endocytic receptor; Immune modulation
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Funding
- Research Agency of the Republic of Slovenia [P1-0208]
- Women in Science UNESCO
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The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a type II C-type lectin whose expression is restricted to the most potent antigen-presenting cells (APCs), the dendritic cells (DCs). In recent years, DC-SIGN has gained an exponential increase in attention because of its involvement in multiple aspects of immune function. Besides being an adhesion molecule, particularly in binding ICAM-2 and ICAM-3, it is also crucial in recognizing several endogenous and exogenous antigens. Additionally, the intracellular domain of DC-SIGN includes molecular motifs, which enable the activation of signal transduction pathways involving Raf-1 and subsequent modulation of DC-maturation status, through direct modification of nuclear factor Nf-kappa B in DCs. Upon DC-SIGN engagement by mannose- or fucose-containing oligosaccharides, the latter leads to a tailored Toll-like receptor signalling, resulting in an altered DC-cytokine profile and skewing of Th1/Th2 responses. In this article, we will discuss recent advances on a broad perspective concerning DC-SIGN structure, signalling and immune function. (C) 2010 Elsevier Inc. All rights reserved.
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