Journal
CELLULAR SIGNALLING
Volume 22, Issue 10, Pages 1406-1412Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2010.03.019
Keywords
Serotonin; 5-HT1A receptors; G protein; MAPK; Akt; Behavior
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Funding
- NIH [MH073723, MH086622, NS061788]
- NATIONAL INSTITUTE OF MENTAL HEALTH [K02MH086622, R01MH073723] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [T32NS061788] Funding Source: NIH RePORTER
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Serotonin is an influential monoamine neurotransmitter that signals through a number of receptors to modulate brain function. Among different serotonin receptors, the serotonin 1A (5-HT1A) receptors have been tied to a variety of physiological and pathological processes, notably in anxiety, mood, and cognition. 5-HT1A receptors couple not only to the classical inhibitory G protein-regulated signaling pathway, but also to signaling pathways traditionally regulated by growth factors. Despite the importance of 5-HT1A receptors in brain function, little is known about how these signaling mechanisms link 5-HT1A receptors to regulation of brain physiology and behavior. Following a brief summary of the known physiological and behavioral effects of 5-HT1A receptors, this article will review the signaling pathways regulated by 5-HT1A receptors, and discuss the potential implication of these signaling pathways in 5-HT1A receptor-regulated physiological processes and behaviors. (C) 2010 Elsevier Inc. All rights reserved.
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