Journal
MECHANISMS OF DEVELOPMENT
Volume 110, Issue 1-2, Pages 203-207Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(01)00568-8
Keywords
crumbs; eye; retina; retinitis pigmentosa; leber congenital amaurosis; apico-basal polarity; epithelial polarity; retinal progenitor; retinoblasts; photoreceptor; outer nuclear layer; inner nuclear layer; bipolar neurons; iris; brain; central nervous system; neural tube; V3 interneurons; Nkx2.2; hypothalamus mammillary bodies; dentate gyrus; olfactory bulbs; subventricular region; rostral migratory stream; neural stem cell; crumbs homologue 1; sonic hedge hog; zona limitans intrathalamica
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Funding
- Telethon [TGM06S01] Funding Source: Medline
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Mutations in the human Crumbs homologue 1 (CRB 1) gene cause severe retinal dystrophies. CRB1 is homologous to Drosophila Crumbs, a protein essential for establishing and maintaining epithelial polarity. We have isolated the mouse orthologue, Crb1, and analyzed its expression pattern in embryonic and post-natal stages. Crb1 is expressed exclusively in the eye, and the central nervous system. In the developing eye, expression of Crb1 is detected in the retinal progenitors, and later on becomes restricted to the differentiated photoreceptor cells where it remains active up to the adult stage. In the developing neural tube, expression of Crb1 is restricted to its most ventral structures, coinciding with the expression domain of Nkx2.2. In the adult brain, Crb1 expression is defined to areas where the production and migration of neurons occurs in adulthood. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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