Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 171, Issue -, Pages 139-147Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2014.08.011
Keywords
Fluoroallcylation; Copper; Cross-coupling; Tatrafluoroethylenation
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Funding
- National Basic Research Program of China [2012CB821600, 2012CB215500]
- National Natural Science Foundation of China [21372246]
- Shanghai QMX Program [13QH1402400]
- Chinese Academy of Sciences
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We have made a systematic investigation on the copper(0)-mediated tetrafluoroethylenation of iodobenzene with structurally diverse 2-bromo-1,1,2,2-tetrafluoroethyl compounds. A comparison of this reaction with 1,2,2-trifluoro-1-phenylethylation and the known functionalized difluoroalkylation demonstrates that the substituent R of alpha,alpha-difluoroalkyl copper species RCF2Cu plays a crucial role on their reactivity, which is believed to be useful for the development of new fluoroalkylation reactions under the promotion of transition metals. (C) 2014 Elsevier B.V. All rights reserved.
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