Journal
CELLULAR SIGNALLING
Volume 21, Issue 8, Pages 1245-1254Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2009.02.012
Keywords
PTH; PTHrP; PTH1R; Osteoblast; Signaling
Categories
Funding
- National Institute of Health [DE016865, DK062286]
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The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic agents. Several studies have been performed, new studies are emerging out and yet controversies remain on PTH anabolic action in bone. This review focuses on the molecular aspects of PTH and PTHrP signaling in light of old players and recent advances in understanding the control of osteoblast proliferation, differentiation and function. (C) 2009 Elsevier Inc. All rights reserved.
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