Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 109, Issue 2, Pages 193-204Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200212529
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Funding
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R43DK041577, P30DK043351, R01DK052778, R01DK048077] Funding Source: NIH RePORTER
- NIDDK NIH HHS [R01 DK-52778, DK-41577, P30 DK043351, R01 DK-48077, R01 DK048077, R01 DK-58889-01, R01 DK052778, DK-43351] Funding Source: Medline
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Trefoil factor family 2 (TFF2), also known as spasmolytic polypeptide, is a member of the trefoil family of peptides and is expressed primarily in the mucous neck cells of the gastric mucosa. To study the physiologic role of TFF2,,we have generated TFF2-deficient mice through targeted gene disruption. Homozygous mutant mice were viable and fertile without obvious gastrointestinal abnormalities. However, quantitative measurements revealed a significant decrease in gastric mucosal thickness and in gastric mucosal proliferation rates, In addition, there was a twofold increase in activated parietal cells resulting in a twofold increase in basal and stimulated gastric acid output and an undetectable serum gastrin level. The TFF2-deficient mice also showed a significant increase in the degree of gastric ulceration after administration of indomethacin. Taken together, these results suggest a physiologic role for TFF2 to promote mucosal healing through the stimulation of proliferation and downregulation of gastric acid secretion.
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