Journal
CELLULAR SIGNALLING
Volume 21, Issue 3, Pages 384-393Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2008.11.001
Keywords
p21-Activated kinase; Brain; Neuronal development; Neurodegenerative diseases; Synaptic plasticity
Categories
Funding
- Fondation Jerome Lejeune
- Association pour la Recherche sur le Cancer
- Ligue contre le Cancer-Essonne
- Fondation pour la Recherche Medicale (PK)
- Agence Nationale de la Recherche
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Group I p21activated kinases are a family of key effectors of Rac1 and Cdc42 and they regulate many aspects of cellular function, such as cytoskeleton dynamics, cell movement and cell migration, cell proliferation and differentiation, and gene expression. The three genes PAK1/2/3 are expressed in brain and recent evidence indicates their crucial roles in neuronal cell fate, in axonal guidance and neuronal polarisation, and in neuronal migration. Moreover they are implicated in neurodegenerative diseases and play an important role in synaptic plasticity, with PAK3 being specifically involved in mental retardation. The main goal of this review is to describe the molecular mechanisms that govern the different functions of group I PAK in neuronal signalling and to discuss the specific functions of each isoform. (c) 2008 Elsevier Inc. All rights reserved.
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