Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 180, Issue -, Pages 186-191Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2015.09.011
Keywords
Ruppert-Prakash reagent; TMSCF3; Difluoromethylation; Thiols; Siladifluoromethylation; Difluoromethyl thioethers; Nucleophilic; (arylsulfanyl)difluoromethylation; RSCF2H; RSCF2TMS
Categories
Funding
- Loker Hydrocarbon Research Institute
Ask authors/readers for more resources
Direct S-difluoromethylation of aryl and aliphatic thiols using the Ruppert-Prakash reagent is demonstrated. The reaction produces trimethylsilyldifluoromethyl sulfides, which upon cleavage with fluoride produces the difluoromethyl sulfides. The key reaction features are the use of relatively inexpensive and commercially available starting materials, shorter reaction times, ambient temperatures, easy reaction procedure, and selective S-difluoromethylation in the presence of-OH, -NH2 and -CO2H functional groups. Furthermore, one-pot arylthiodifluoromethyl transfer to PhCHO is also demonstrated. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available