Journal
CELLULAR SIGNALLING
Volume 21, Issue 1, Pages 7-13Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2008.07.011
Keywords
Sphingosine 1-phosphate; Sphingosine kinase; Neurotransmitter; Alzheimer's disease; Neuron; Central nervous system; Apoptosis
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Funding
- Ministry of Education, Science, Sports and Culture of Japan
- Japan Society for the Promotion of Science and Polish Academy of Sciences
- Osaka Medical Research Foundation for Incurable Diseases
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Sphingolipids were once regarded as inert structural components of cell membranes. Now these metabolites are generally believed to be important bioactive molecules that control a wide repertoire of cellular processes such as proliferation and survival of cells. Along with these ubiquitous cell functions observed in many peripheral tissues sphingolipid metabolites, especially sphingosine 1-phosphate, exert important neuron-specific functions such as regulation of neurotransmitter release. This review summarizes physiological and pathological roles of sphingolipid metabolites emphasizing the role of sphingosine 1-phosphate in the central nervous system. (C) 2008 Elsevier Inc. All rights reserved.
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