Journal
CELLULAR SIGNALLING
Volume 21, Issue 11, Pages 1548-1558Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2009.05.001
Keywords
Proteoglycan; Co-receptor; Signaling; Adhesion; Migration; Invasion; Cancer; Wound healing
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Funding
- NCI NIH HHS [R01 CA106307-01, R01 CA136786, R01 CA135006, R01 CA106307] Funding Source: Medline
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Signaling co-receptors are diverse, multifunctional components of most major signaling pathways, with roles in mediating and regulating signaling in both physiological and pathophysiological circumstances. Many of these signaling co-receptors, including CD44, glypicans, neuropilins, syndecans and T beta RIII/betaglycan are also proteoglycans. Like other co-receptors, these proteoglycan signaling co-receptors; can bind multiple ligands, promoting the formation of receptor signaling complexes and regulating signaling at the cell surface. The proteoglycan signaling co-receptors can also function as structural molecules to regulate adhesion, cell migration, morphogenesis and differentiation. Through a balance of these signaling and structural roles, proteoglycan signaling co-receptors can have either tumor promoting or tumor suppressing functions. Defining the role and mechanism of action of these proteoglycan signaling co-receptors should enable more effective targeting of these co-receptors and their respective pathways for the treatment of human disease. (C) 2009 Elsevier Inc. All rights reserved.
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