Journal
JOURNAL OF NATURAL PRODUCTS
Volume 65, Issue 1, Pages 21-24Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np010348n
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Funding
- NATIONAL CANCER INSTITUTE [U19CA052955, U01CA052955] Funding Source: NIH RePORTER
- NCI NIH HHS [CA52955] Funding Source: Medline
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Examination of a Lyngbya majuscula collection from Antany Mora, Madagascar, led to the isolation of dolastatin 16 (5), a promising antineoplastic metabolite first reported from the marine mollusc Dolabella auricularia. In addition, a new series of depsipeptides, antanapeptins A-D (1-4), were discovered. Their structures were deduced by 2D NMR and mass spectrometry and are analogous to the molluscan kulomo'opunalides and the recently reported cyanobacterial metabolites, georgamide and the yanucamides. The antanapeptins were evaluated in several biological assays; however, this series did not exhibit activity.
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