Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 25, Issue 1, Pages 125-127Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.25.125
Keywords
Caragana chamlague; Leguminosae; AChE inhibitors; (+)-alpha-viniferin; kobophenol A
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In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha -viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of I and 2 were 2.0 and 115.8 mum, respectively. The AChE inhibitory activity of I was specific, reversible and noncompetitive.
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