Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 47, Issue 3, Pages 482-491Publisher
WILEY
DOI: 10.1002/mrm.10085
Keywords
magnetic resonance imaging; echo-planar imaging; heart; myocardial perfusion; canine
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [Z01HL004607, ZIAHL004607] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The purpose of this study was to validate a first-pass MRI method for imaging myocardial perfusion with multislice coverage and relatively small analyzable regions of interest (ROIs). A fast gradient-echo (FGRE) sequence with an echo-train (ET) readout was used to achieve multislice coverage, and a high dose of a contrast agent (CA) was used to achieve a high signal-to-noise ratio (SNR). Dogs (N = 6) were studied 1 day after reperfused myocardial infarction, and fluorescent microspheres were used as a standard for perfusion. First-pass MRI correlated well vs. microsphere flow, achieving mean R values of 0.87 (range = 0.82-0.93), 0.71 (range = 0.46-0.85), and 0.72 (range = 0.49-0.95) for subendocardial ROIs, transmural ROIs, and the endocardial-epicardial ratio, respectively. Additionally, analysis of myocardial time-intensity curves (TICs) indicated that 15.8 +/- 6.6degrees sectors, corresponding to 260 mul of endocardium, can be analyzed (R-2 > 0.95). Published 2002 Wiley-Liss, Inc.(dagger)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available