Journal
NATURE NEUROSCIENCE
Volume 5, Issue 3, Pages 267-271Publisher
NATURE AMERICA INC
DOI: 10.1038/nn804
Keywords
-
Categories
Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [ZIAMH002652, Z01MH002716, ZIAMH002717, Z01MH002652, Z01MH002717, ZIAMH002716] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Both dopaminergic neurotransmission and prefrontal cortex (PFC) function are known to be abnormal in schizophrenia. To test the hypothesis that these phenomena are related, we measured presynaptic dopaminergic function simultaneously with regional cerebral blood flow during the Wisconsin Card Sorting Test (WCST) and a control task in unmedicated schizophrenic subjects and matched controls. We show that the dopaminergic uptake constant K-i in the striatum was significantly higher for patients than for controls. Patients had significantly less WCST-related activation in PFC. The two parameters were strongly linked in patients, but not controls. The tight within-patient coupling of these values, with decreased PFC activation predicting exaggerated striatal 6-fluorodopa uptake, supports the hypothesis that prefrontal cortex dysfunction may lead to dopaminergic transmission abnormalities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available