Journal
MOLECULAR CELL
Volume 9, Issue 3, Pages 601-610Publisher
CELL PRESS
DOI: 10.1016/S1097-2765(02)00471-9
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Funding
- NCI NIH HHS [CA57374] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA057374] Funding Source: NIH RePORTER
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Androgen receptor (AR) is required for sexual differentiation and is implicated in the development of prostate cancer. Here we describe distinct functions for cofactor proteins and gene regulatory elements in the assembly of AR-mediated transcription complexes. The formation of an activation complex involves AR, coactivators, and RNA polymerase H recruitment to both the enhancer and promoter, whereas the formation of a repression complex involves factors bound only at the promoter and not the enhancer. These results suggest a model for the functional coordination between the promoter and enhancer in which communication between these elements is established through shared coactivators in the AR transcription complex.
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