Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 124, Issue 1-2, Pages 9-15Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00004-8
Keywords
corticosterone resistance; stress; spleen; liver; mice; lipopolysaccharide
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH046801, F31MH011792] Funding Source: NIH RePORTER
- NIMH NIH HHS [F31 MH11792, R01 MH46801-08] Funding Source: Medline
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Following social disruption (SDR) stress in male mice, corticosterone resistance of splenocytes was accompanied by enhanced LPS-stimulated interleukin (IL)-6 secretion. The present study examined the role of IL-6 in the development of corticosterone resistance. Addition of IL-6 to control splenocyte cultures did not induce corticosterone resistance. SDR also elevated IL-6 in plasma and liver, but not in spleen. IL-6 deficient mice that were exposed to SDR developed glucocorticoid resistance despite the absence of systemic IL-6. These findings suggest that although SDR enhanced IL-6 responses, IL-6 was not essential for the development of stress-induced splenocyte corticosterone resistance. (C) 2002 Elsevier Science B.V. All rights reserved.
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