Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 21, Issue 3, Pages 221-227Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00006454-200203000-00012
Keywords
rotavirus; surveillance; clinical presentations
Categories
Funding
- NIAID NIH HHS [N01 AI 45252] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [N01AI045252] Funding Source: NIH RePORTER
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Background. Although rotaviruses (RVs) are the most common cause of severe gastroenteritis in children, there is a lack of information detailing the spectrum of clinical manifestations of RV disease resulting in hospitalization. Objective. To characterize the clinical spectrum of RV-associated hospitalizations, including short stay visits in children. Methods. Active RV disease surveillance was conducted at three children's hospitals Sundays through Thursdays in children 15 days through 4 years of age admitted with diarrhea (D), vomiting (V) and/or unexplained fever (F) between November, 1997, and June, 1998. Stool specimens were collected and tested for RV by enzyme immunoassay. Results. Of the 862 children enrolled, 763 (88%) had a stool specimen tested for RV. Overall 31% of children excreted RV. RV excretion was highest when all 3 symptoms (D, V and F) occurred in the same child (56%), lower when 2 symptoms occurred together (38% DV; 19% DF; 13% VF) and lowest when each symptom occurred alone (3% D; 11% V, 6% F). Nine percent of the children without diarrhea excreted RV. Children admitted without diarrhea were more likely to have rotavirus if they developed diarrhea during their hospitalization. Conclusions. RV detection was greatest when diarrhea, vomiting and fever occurred together and lowest when each symptom occurred alone. The spectrum of symptoms of rotavirus disease in children at the time of admission to the hospital or short stay unit may be broader than previously recognized.
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