Journal
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Volume 29, Issue 1-2, Pages 111-120Publisher
KARGER
DOI: 10.1159/000337592
Keywords
NPY; Brainstem; Substance P; GluR2; GABA(A)R
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Funding
- Natural Science Foundation of China [30870862]
- National Natural Science Foundation of China [81121003]
- New Century Excellent Talents in University
- Ministry of Education of China [NCET-08]
- Special Fund for Innovation Talent by Harbin Science and Technology [2008RFLXS009]
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Neuropeptide Y (NPY) is an important neuronal element involved in cardiovascular regulation. Since elevated plasma levels of NPY have been observed in numerous pathological situations, this study aimed to determine whether long-term elevated plasma concentrations of NPY could result in aberrant baroreflex sensitivity. Mini-osmotic pump containing NPY (85 mu g per 30 days) was subcutaneously implanted between scapulae in male rats for 4 months. The rats treated with NPY showed the following characters compared with control group: (1) attenuated heart rate responding to the increases in mean arterial blood pressure (MABP) induced by phenylephrine, but enhanced heart rate responding to the decreases in MABP induced by sodium nitroprusside; (2) decreased protein levels of substance P (SP) and GluR2, while increased the expression of gamma-aminobutyric acid A receptor (GABA(A)R) in brainstem; (3) abdominal obesity indicated by increased body weight and accumulated fat mass in peritoneal cavity; (4) significant increases in total cholesterol, triglycerides, and low density lipoprotein levels in the periphery. These findings indicate that long-term NPY administration in the periphery leads to abnormal baroreflex sensitivity due, at least in part, to the down-regulated expression of SP/GluR2 and elevated expression of GABA(A)R in both protein and RNA levels, which indicate the alternations in glutamate function and GABA action in the nucleus tractus solitarii in NPY-treated rats. Furthermore, long-term NPY administration results in abdominal obesity and dyslipidemia. Copyright (C) 2012 S. Karger AG, Basel
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