Journal
NATURE REVIEWS IMMUNOLOGY
Volume 2, Issue 1, Pages 20-27Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri703
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This review examines the value of transgenic studies in mice for the genetic dissection of signal-transduction pathways relevant to thymus development. T-cell development in the thymus is controlled by an ordered sequence of differentiation and proliferation checkpoints that culminate in the production of correctly selected, non-autoreactive, peripheral T lymphocytes. Work in transgenic mice has been fundamental for the preparation of genetic maps of signal-transduction pathways that control T-cell development. This review discusses how tyrosine kinases, guanine-nucleotide- binding proteins and transcription factors converge to control T-cell differentiation and proliferation in the immune system.
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